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icobrain mr

  • Traumatic Brain Injury
  • Dementia
  • Multiple Sclerosis
  • MRI

icobrain mr is intended for automatic labeling, visualization and volumetric quantification of segmentable brain structures from a set of MR images. This icobrain mr software is intended to automate the current manual process of identifying, labeling and quantifying the volume of segmentable brain structures identified on MR images.

icobrain viewer

Images shown for illustrative purposes only.

Circle

74% faster detection of treatment failure in MS using icobrain vs drugs alone1

Circle

68% outcome improvements when employing icobrain vs drug alone (simulated data)1

Clinical Workflow

icobrain dm

icobrain dm workflow

icobrain tbi

icobrain tbi workflow

icobrain ms

icobrain ms workflow

For CalanticTM 1.0, no prior study will be examined for comparison.

white bg

 

    As input, icobrain mr uses:

     

    For Dementia:

    • 3D T1-weighted images.
    • Parameters:

      - Pixel spacing 1mm x 1mm

      - Slice thickness: preferred<=1.0 mm, allowed<=1.5mm.

      - Body part examined: entire head (bran + skull).

     

    For Multiple Sclerosis:

    • 3D T1-weighted images and a 3D or 2D (max 3 mm slice thickness) fluid-attenuated inversion recovery (FLAIR) DICOM MR images.
    • Parameters:

      - Pixel spacing 1 mm x 1 mm.

      - Slice thickness: Flair (preferred<=1.5 mm, allowed<=3.0mm), T1 (preferred<=1.0 mm, allowed<=1.5 mm).

      - Body part examined: entire head (bran + skull).

     

    For Traumatic Brain Injury (TBI):

    • MRI Brain sequences - 3D T1 pre and/or post contrast and 2D or 3D Flair
    • Parameters:

      - Pixel Spacing: 1mm x 1mm.

      - Slice thickness: (preferred: FLAIR≤1.5 mm T1≤1.0mm, allowed: FLAIR≤ 3.0mm T1<1.5mm.

      - Body part examined: Entire head (brain + skull).

     

    *Scanning Parameters are derived from the HCP Manual icobrain mr 5.12.0 v.104. To request these documents, please contact the vendor.

    For Dementia:

    • normalized volume and volume changes of the frontal, temporal, parietal lobe and occipital lobe
    • normalized volume and volume changes of the hippocampi (HC), inferior lateral ventricles (ILV), and their ratio (ILV/HC)
    • normalized volume and volume changes of the whole brain (WB), lateral ventricles (LV), and their ratio (LV/WB)
    • asymmetry index between the left and right hippocampi, frontal, temporal, parietal lobe and occipital lobes

     

    For Multiple Sclerosis:

    • unnormalized volume and volume changes (total, new, enlarging and shrinking) of FLAIR white matter hyperintensities, in different regions (periventricular, juxta-cortical, infra-tentorial, deep white matter)
    • unnormalized volume and volume changes (total, new, enlarging and shrinking) of T1 white matter hyperintensities and hypointensities
    • normalized volume and volume changes of the whole brain (sum of white and gray matter)
    • normalized volume and volume changes of gray matter

     

    For Traumatic Brain Injury (TBI):

    • unnormalized volume and volume changes (total, new, enlarging and shrinking) of FLAIR white matter hyperintensities, in different regions (subcortical, corpus callosum, brainstem)
    • normalized volume and volume changes of the cortical gray matter
    • normalized volume and volume changes of the hippocampi

      EU risk class and CE marking
      icobrain mr have CE marking (CE1639) and risk class Im.

      Reimbursement status
      Not reimbursed.

      Contraindications
      No contraindications given.

      Target population
      Patients with a neurological disorder.

      Intended user
      Healthcare professionals who treat and/or diagnose patients with a neurological disorder.

      Limitations
      Artifacts and anatomical deviations: Please make sure the images are free of artifacts and do not show evidence of surgical intervention (i.e., craniotomy, craniectomy, burr holes, external ventricular drains (EVD), intracranial pressure monitoring devices, etc) or other concomitant pathologies (e.g., such as a tumor, haemorrhages, etc), as these might have a negative impact on the results of fully automatic measurements. Even without artifacts or extensive deviations in anatomy, automatic measurements are subject to errors, intrinsically associated with the measurement device.

        1.
        Instructions for Use icobrain mr, software version 5.8
        2.
        Sima DM, Esposito G, Van Hecke W, et al Health Economic Impact of Software-Assisted Brain MRI on Therapeutic Decision-Making and Outcomes of Relapsing-Remitting Multiple Sclerosis Patients-A Microsimulation Study. Brain Sci. 2021 Nov 27;11(12):1570. doi: 10.3390/brainsci11121570. PMID: 34942872; PMCID: PMC8699604.
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