icobrain mr
- Traumatic Brain Injury
- Dementia
- Multiple Sclerosis
- MRI
icobrain mr is intended for automatic labeling, visualization and volumetric quantification of segmentable brain structures from a set of MR images. This icobrain mr software is intended to automate the current manual process of identifying, labeling and quantifying the volume of segmentable brain structures identified on MR images.
Images shown for illustrative purposes only.
74% faster detection
of treatment failure in MS using icobrain vs drugs alone2
68% outcome improvements
when employing icobrain vs drug alone (simulated data)2
Clinical Workflow
icobrain dm
icobrain tbi
icobrain ms
For CalanticTM 1.0, no prior study will be examined for comparison.
As input, icobrain mr uses:
For Dementia:
- 3D T1-weighted images.
- Parameters:
- Pixel spacing 1mm x 1mm
- Slice thickness: preferred<=1.0 mm, allowed<=1.5mm.
- Body part examined: entire head (bran + skull).
For Multiple Sclerosis:
- 3D T1-weighted images and a 3D or 2D (max 3 mm slice thickness) fluid-attenuated inversion recovery (FLAIR) DICOM MR images.
- Parameters:
- Pixel spacing 1 mm x 1 mm.
- Slice thickness: Flair (preferred<=1.5 mm, allowed<=3.0mm), T1 (preferred<=1.0 mm, allowed<=1.5 mm).
- Body part examined: entire head (bran + skull).
For Traumatic Brain Injury (TBI):
- MRI Brain sequences - 3D T1 pre and/or post contrast and 2D or 3D Flair
- Parameters:
- Pixel Spacing: 1mm x 1mm.
- Slice thickness: (preferred: FLAIR≤1.5 mm T1≤1.0mm, allowed: FLAIR≤ 3.0mm T1<1.5mm.
- Body part examined: Entire head (brain + skull).
*Scanning Parameters are derived from the HCP Manual icobrain mr 5.12.0 v.104. To request these documents, please contact the vendor.
For Dementia:
- normalized volume and volume changes of the frontal, temporal, parietal lobe and occipital lobe
- normalized volume and volume changes of the hippocampi (HC), inferior lateral ventricles (ILV), and their ratio (ILV/HC)
- normalized volume and volume changes of the whole brain (WB), lateral ventricles (LV), and their ratio (LV/WB)
- asymmetry index between the left and right hippocampi, frontal, temporal, parietal lobe and occipital lobes
For Multiple Sclerosis:
- unnormalized volume and volume changes (total, new, enlarging and shrinking) of FLAIR white matter hyperintensities, in different regions (periventricular, juxta-cortical, infra-tentorial, deep white matter)
- unnormalized volume and volume changes (total, new, enlarging and shrinking) of T1 white matter hyperintensities and hypointensities
- normalized volume and volume changes of the whole brain (sum of white and gray matter)
- normalized volume and volume changes of gray matter
For Traumatic Brain Injury (TBI):
- unnormalized volume and volume changes (total, new, enlarging and shrinking) of FLAIR white matter hyperintensities, in different regions (subcortical, corpus callosum, brainstem)
- normalized volume and volume changes of the cortical gray matter
- normalized volume and volume changes of the hippocampi
EU risk class and CE marking
icobrain mr have CE marking (CE1639) and risk class Im.
Reimbursement status
Not reimbursed.
Contraindications
No contraindications given.
Target population
Patients with a neurological disorder.
Intended user
Healthcare professionals who treat and/or diagnose patients with a neurological disorder.
Limitations
Artifacts and anatomical deviations: Please make sure the images are free of artifacts and do not show evidence of surgical intervention (i.e., craniotomy, craniectomy, burr holes, external ventricular drains (EVD), intracranial pressure monitoring devices, etc) or other concomitant pathologies (e.g., such as a tumor, haemorrhages, etc), as these might have a negative impact on the results of fully automatic measurements. Even without artifacts or extensive deviations in anatomy, automatic measurements are subject to errors, intrinsically associated with the measurement device.
Discover icobrain mr
Now available as part of Calantic’s Neuro Service Line. Contact us today to learn more.
