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Home > App Gallery > IB Clinic

imaging

IB Clinic

  • Oncology
  • MRI
  • DSC
  • DCE
  • Diffusion
  • Delta T1

IB Clinic is designed to aid trained physicians in advanced image assessment, treatment consideration, and monitoring of therapeutic response. It generates various perfusion and diffusion related parameters, standardized image sets, and image intensity differences.

imaging viewer

Images shown for illustrative purposes only.

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86% Accuracy with spatially correlated tissue2

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Demonstrated ability to estimate tumour burden3

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96% Accuracy with spatially correlated tissue1

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Demonstrated ability to estimate tumour burden1

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Most Proven Contrast Leakage Algorithm1

Clinical Workflow

IB workflow

For CalanticTM software version 1.0.0, no prior study will be examined.

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    Scanning Parameters

    IB DCE

    • Image process: DCE Perfusion Weighted MR Imaging (DCE-MRI)
    • Slice thickness: 3-5mm
    • Reconstruction: Axial
    • Matrix size: Any
    • Minimum contiguous volume: Any
    • Maximum contiguous volume: Any
    • Repetition time: Shortest TR<500ms , Shortest TE<10 ms
    • Flip angle: Small FA=20º

     

    IB Diffusion

    • Image process: MR Diffusion Weighted Imaging (DWI)
    • Slice thickness: 3-5mm
    • Reconstruction: Axial
    • Matrix size: Any
    • Minimum contiguous volume: Sufficient for tumor coverage

     

    IB Neuro

    • Image process: DSC Perfusion Weighted MR Imaging (DSC-MRI)
    • Slice thickness: 3-5mm
    • Reconstruction: Axial
    • Matrix size: Any
    • Minimum contiguous volume: Sufficient for tumor coverage
    • Maximum contiguous volume: Chosen such that TR>2s with tumor coverage
    • Repetition time: 1000 – 15000ms
    • Flip angle: 60º or 30º w/preload at 1.5T 30o no preload at 3T

     

    IB Delta T1

    • Image process: MR T1-weighted images (with and without contrast)
    • Slice thickness: 3-5mm
    • Reconstruction: Axial
    • Matrix size: Any
    • Repetition time: Any
    • Flip angle: Any
    • Scanning considerations: Keep the same parameter setting for both pre and post-contrast T1
    AI Output

    IB DCE

    • Transfer constant from the blood plasma into the extravascular (Ktrans)
    • Extravascular, extracellular fraction of the whole tissue volume (ve)
    • Blood plasma fraction of the whole tissue volume (vp)
    • Transfer constant from the extravascular, extracellular space back to the blood plasma (kep)
    • Initial slope (IS) also known as Wash-in
    • Wash-out (WO)
    • Peak Enhancement (PE)
    • Initial Area Under the Cover (IAUC)
    • Time-to-Peak (TTP)
    • Relative Time-to-Peak (rTTP)

     

    IB Diffusion

    • Apparent Diffusion Coefficient (ADC)
    • Distributed Diffusion Coefficient (DDC)
    • Intra-voxel heterogeneity index (Alpha)

     

    IB Neuro

    • Relative Cerebral Blood Volume (rCBV)
    • Relative Cerebral Blood Flow (rCBF)
    • Mean Transit Time (MTT)
    • Time-to-Peak (TTP)
    • Relative Time-to-Peak (rTTP)
    • Percent Signal Recovery (PSR)

     

    IB Delta T1

    • Delta T1 (dT1)

    What Customers Are Saying

    They [IB Neuro derived maps] have proven to provide information that can help interpret MRI findings and optimize treatment for our patients.

    Dr. Jennifer Connelley, MD, Associate Professor of Neurology and Co-Director of the Neuro-Oncology Program at Froedtert and the Medical College of Wisconsin

    May not reflect a typical user experience; actual results may vary.

    What Customers Are Saying

    We appreciate the speed of IB products and their compatibility with PACS. More recently, we have started to use IB products for image-guided surgical planning. We anticipate their use for radiation therapy planning in the near future. Our neurosurgeons,radiation oncologists, and neuro oncologists find perfusion scans and Delta T1 maps of the brain to be very useful, and now routinely write orders to obtain this information.

    Dr. Scott Rand, MD PhD Professor of Radiology at Froedtert Health and the Medical College of Wisconsin

    May not reflect a typical user experience; actual results may vary.

    What Customers Are Saying

    The T1 with contrast is hard to interpret, but I think the Delta T1 says it all.

    Dr. Jennifer Connelley, MD, Associate Professor of Neurology and Co-Director of the Neuro-Oncology Program at Froedtert and the Medical College of Wisconsin

    May not reflect a typical user experience; actual results may vary.

    What Customers Are Saying

    IB Software ... They have cut down my analysis time from hours to minutes.

    Cathy Marszalkowski, Research Coordinator at Froedtert Health and the Medical College of Wisconsin

    May not reflect a typical user experience; actual results may vary.

      Other Relevant Information

      EU risk class and CE marking
      IB Clinic has CE marking and risk class I.

      Reimbursement status
      Not reimbursed.

      Contraindications
      No contraindications given.

      Target population
      Not indicated.

      Limitations
      Not Indicated.

        References
        1.
        Instructions for Use IB Clinic, software version 2.0
        2.
        Prah MA, Al-Gizawiy MM, Mueller WM, et al Spatial discrimination of glioblastoma and treatment effect with histologically-validated perfusion and diffusion magnetic resonance imaging metrics. J Neurooncol. 2018 Jan;136(1):13-21. doi: 10.1007/s11060-017-2617-3. Epub 2017 Sep 12. PMID: 28900832; PMCID: PMC5756123.
        3.
        Hoxworth JM, Eschbacher JM, Gonzales AC, et al Performance of Standardized Relative CBV for Quantifying Regional Histologic Tumor Burden in Recurrent High-Grade Glioma: Comparison against Normalized Relative CBV Using Image-Localized Stereotactic Biopsies. AJNR Am J Neuroradiol. 2020 Mar;41(3):408-415. doi: 10.3174/ajnr.A6486. Epub 2020 Mar 12. PMID: 32165359; PMCID: PMC7077911.
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